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Anabolic Signaling Dominance

Meaning

Anabolic Signaling Dominance describes a physiological state where pathways promoting tissue accretion and synthesis significantly outweigh those promoting breakdown. Clinically, this signifies a net positive balance in processes like protein synthesis relative to proteolysis. Achieving this dominance is crucial for hypertrophy and tissue repair following physiological stress or training stimuli. We look for elevated activity in pathways such as mTORC1 signaling relative to the ubiquitin-proteasome system. Maintaining this state is fundamental to effective anabolic conditioning.