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Anabolic Signaling Deficits

Meaning

Anabolic Signaling Deficits describe a clinical state of impaired cellular responsiveness to anabolic hormones, such as testosterone, growth hormone, and insulin-like growth factor 1 (IGF-1). This deficit results in a significantly reduced capacity for protein synthesis, tissue growth, and cellular repair in target tissues like muscle and bone. The condition fundamentally shifts the body toward a net catabolic state, compromising the maintenance of lean body mass and contributing to age-related sarcopenia and fragility. Effective management requires precise interventions to restore cellular communication and drive tissue accretion.