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Anabolic Signaling Bypass

Meaning

Anabolic Signaling Bypass refers to a pharmacological or physiological strategy designed to activate intracellular anabolic pathways independently of, or downstream from, the body’s primary endogenous hormone-receptor mechanisms. This approach is employed when natural hormonal signaling is impaired due to receptor desensitization, binding protein interference, or enzymatic deficiency. By circumventing the compromised step in the signaling cascade, the therapeutic goal is to restore or enhance protein synthesis and cellular regeneration. This sophisticated method is key to overcoming specific forms of anabolic resistance.