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Anabolic Signaling Blockade

Meaning

A state of impaired or inhibited cellular signaling pathways responsible for promoting growth, repair, and tissue synthesis, often observed in conditions of chronic stress, nutritional deficiency, or hormonal dysregulation. This blockade specifically impacts the body’s ability to respond effectively to anabolic stimuli, such as resistance training or adequate protein intake, leading to a net catabolic state. It is a critical factor in the progressive loss of muscle mass and bone density associated with aging, known as sarcopenia and osteopenia.