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Anabolic Signaling Balance

Meaning

Anabolic Signaling Balance refers to the critical physiological equilibrium maintained between anabolic pathways, which promote tissue growth and synthesis, and catabolic pathways, which drive tissue breakdown and degradation. This homeostatic balance, particularly in skeletal muscle and bone, is essential for maintaining lean body mass, metabolic health, and structural integrity throughout the lifespan. A sustained shift toward catabolism is the fundamental molecular driver of sarcopenia, frailty, and other age-related declines in functional capacity. Hormones, nutrients, and mechanical loading are the primary external factors that constantly modulate this delicate equilibrium.