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Anabolic Resistance Induction

Meaning

Anabolic resistance induction refers to a physiological state where the body’s tissues, particularly skeletal muscle, exhibit a blunted or reduced sensitivity to anabolic stimuli, such as amino acids or hormones like insulin and testosterone. This condition impairs the normal signaling pathways required for protein synthesis and tissue repair, making it difficult to build or maintain lean mass. It is a common feature of aging (sarcopenia), chronic disease, and periods of severe catabolic stress. Overcoming this resistance is a primary clinical goal for improving physical resilience and longevity.