What is the Origin of Anabolic Resistance Correction?

The term "anabolic resistance" emerged from nutritional and exercise physiology research focused on muscle metabolism in older adults and catabolic states. "Anabolic" comes from the Greek anabolē, meaning "a raising up," referring to the synthesis of complex molecules from simpler ones. The clinical goal of "Correction" signifies a therapeutic intervention to restore normal physiological function, moving the body out of a catabolic-dominant state.

What is the Mechanism of Anabolic Resistance Correction?

Correction strategies typically involve a combination of resistance training, which mechanically sensitizes muscle fibers, and precise nutritional timing, especially with essential amino acids like leucine. At the cellular level, the mechanism targets improving the efficiency of the mTOR signaling pathway, which is the master regulator of protein synthesis, and enhancing insulin sensitivity at the muscle receptor site. Restoring optimal circulating levels of key anabolic hormones, where clinically indicated, also plays a crucial role in potentiating the muscle cell's response to these essential growth signals.

Anabolic Resistance Correction

Meaning

Anabolic Resistance Correction is the clinical process of reversing the impaired responsiveness of skeletal muscle tissue to anabolic stimuli, such as amino acids and key hormones like insulin and testosterone. This condition, prevalent in aging and certain chronic diseases, leads to a reduced rate of muscle protein synthesis despite adequate protein intake. Successful correction restores the muscle cell’s sensitivity, promoting efficient protein turnover and facilitating the maintenance or accretion of lean body mass. This is a critical focus for preventing sarcopenia and maintaining metabolic health.