The clinical objective of reversing endogenous deficits that impair the body’s capacity for tissue synthesis, repair, and maintenance, primarily through optimizing anabolic hormone signaling. This involves evaluating the functional status of the growth hormone/IGF-1 axis and sex steroid production relative to biological need. True restoration requires addressing upstream regulatory elements, not just downstream hormone levels.
Origin
Rooted in the study of sarcopenia and functional decline, this term describes therapeutic efforts to re-establish a positive nitrogen balance and support musculoskeletal integrity. It contrasts with simple hormone replacement by focusing on maximizing inherent physiological capacity.
Mechanism
Restoration mechanisms frequently target the sensitivity of target tissues to endogenous anabolic signals, perhaps through improving insulin signaling or reducing chronic inflammatory states that inhibit mTOR pathways. Modulating factors like ghrelin or optimizing sleep architecture are often integral to reawakening the body’s intrinsic anabolic drive.
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