Therapeutic intervention aimed at restoring circulating levels of hormones, such as testosterone or growth hormone, to optimal physiological ranges to promote net positive protein balance and tissue accretion. This process directly supports lean body mass maintenance and recovery from catabolic states. Clinical assessment confirms the necessity for such intervention based on clinical phenotype and laboratory assay results.
Origin
This term originates in the intersection of endocrinology and sports medicine, describing the targeted restoration of anabolic signaling following states of deficiency or suppression. The focus is on rebuilding endogenous capacity or supplementing necessary substrates for tissue synthesis. It contrasts with simple supplementation by emphasizing the goal of physiological restoration.
Mechanism
Repletion works by providing the necessary substrate for anabolic signaling cascades, often involving activation of the Akt/mTOR pathway in skeletal muscle and other tissues. Increased receptor occupancy drives protein synthesis rates beyond baseline catabolic flux. This mechanism ultimately enhances nitrogen retention and muscular hypertrophy potential within the body’s cellular machinery.
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