The clinical process of restoring anabolic hormone levels, such as testosterone, DHEA, or growth hormone, to their optimal, youthful physiological range. This intervention aims to counteract the age-related decline in these crucial hormones, which are vital for tissue building and repair. Reinstatement is distinct from simple supplementation as it focuses on achieving a functional, balanced state that supports systemic health and vitality.
Origin
The term combines ‘anabolic,’ derived from the Greek anabole meaning ‘a raising up’ or ‘building up,’ with ‘hormone’ from the Greek hormao meaning ‘I excite’ or ‘I set in motion.’ ‘Reinstatement’ refers to the clinical goal of returning levels to a previous, healthier set point, reflecting a core principle of restorative endocrinology.
Mechanism
The mechanism involves introducing exogenous hormones or stimulating endogenous production to engage target tissue receptors, thereby promoting protein synthesis and cellular proliferation. This action increases lean body mass, enhances bone density, and improves metabolic function by shifting the body’s balance away from catabolism. Precise dosing and monitoring are essential to ensure receptor sensitivity and mitigate potential side effects, optimizing the therapeutic index.
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