This refers to the intricate endocrine control governing processes that promote the synthesis of complex molecules from simpler ones, particularly protein synthesis and tissue accretion. Precise regulation ensures appropriate growth, repair, and maintenance of lean body mass, which is critical for metabolic health. Dysregulation often manifests as sarcopenia or altered substrate utilization throughout the body.
Origin
The term combines ‘anabole’ (Greek for upward building) with ‘hormone’ (Greek for setting in motion) and ‘regulation’ (Latin for rule or guide). This concept anchors itself deeply within endocrinology, describing the stewardship of tissue-building signals. The regulatory network involves the hypothalamic-pituitary-gonadal or -adrenal axes.
Mechanism
Key anabolic hormones like testosterone, growth hormone (GH), and insulin act via receptor binding to initiate intracellular signaling cascades, such as the $text{PI3K/Akt/mTOR}$ pathway. These signals ultimately increase ribosomal efficiency and decrease protein catabolism, thereby tipping the net protein balance toward synthesis. Effective management of these signals is central to maintaining physiological homeostasis and functional capacity.
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