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Amygdala-Prefrontal Cortex Axis

Meaning

This axis describes the functional, bidirectional connectivity between the amygdala and the prefrontal cortex (PFC), representing a core circuit for emotional regulation and executive control. The amygdala is primarily responsible for processing salient emotional stimuli, particularly fear and threat, initiating rapid responses. Conversely, the prefrontal cortex is the seat of higher-order cognitive functions, including planning and inhibitory control over emotional responses. The integrity and balance of this neuroanatomical axis are fundamental to resilience and mental wellness in the face of stress.