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AMPK mTOR Pathway

Meaning

The AMPK-mTOR pathway represents a critical, evolutionarily conserved cellular signaling network that functions as the primary regulator of energy homeostasis, cell growth, and metabolism. AMP-activated protein kinase (AMPK) acts as the cellular fuel sensor, while the mammalian target of rapamycin (mTOR) complex controls anabolic processes like protein synthesis and cell proliferation. These two pathways operate in a reciprocal, antagonistic manner, essentially balancing the body’s energy demands with its nutrient availability. Maintaining this balance is central to metabolic health, cellular repair, and longevity, profoundly impacting hormonal signaling.