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AMPK Metabolic Pathway

Meaning

AMP-activated protein kinase (AMPK) is a critical cellular energy sensor and master regulator of metabolic homeostasis, often termed the “metabolic master switch.” This enzyme complex detects changes in the cellular AMP-to-ATP ratio, signaling a state of low energy or nutrient scarcity. Activating this pathway is fundamentally linked to cellular longevity and improved insulin sensitivity, influencing overall hormonal balance and systemic health. Its function is central to understanding the body’s adaptation to exercise and caloric restriction, promoting a catabolic state to generate energy.