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AMPK/GLUT4 Pathway

Meaning

The AMPK/GLUT4 Pathway is a vital cellular signaling cascade responsible for maintaining energy homeostasis, particularly in skeletal muscle and adipose tissue. This pathway involves the activation of Adenosine Monophosphate-activated Protein Kinase (AMPK) and the subsequent translocation of Glucose Transporter Type 4 (GLUT4) to the cell membrane. It represents a non-insulin-dependent mechanism for increasing glucose uptake, which is highly relevant to metabolic health and insulin sensitivity. Clinically, its function is paramount for regulating blood sugar levels during periods of high energy demand, such as intense physical activity.