This term refers to short sequences of amino acids, known as peptides, that function as molecular messengers to initiate or modulate specific cellular responses within the endocrine system and human physiology. These chains are distinct from structural proteins and are critical for communication between cells and tissues. They play a pivotal role in regulating processes like growth, metabolism, and immune function.
Origin
The foundation of this concept lies in classical biochemistry and molecular endocrinology, where the discovery of peptide hormones like insulin and growth hormone established the signaling function of amino acid chains. The modern term emphasizes the precise, chain-like nature of these messengers and their regulatory role beyond simple nutritional building blocks.
Mechanism
Signaling chains operate by binding to highly specific receptors located on the surface of target cells, acting as a lock-and-key system. This binding event triggers an intracellular cascade of biochemical reactions, often involving secondary messengers, that ultimately alters the cell’s function, such as gene expression or enzyme activity. The specificity of the amino acid sequence dictates the biological effect, making them highly targeted therapeutic agents.
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