The process describing the efficient transport and assimilation of synthesized or supplemented polypeptide sequences across biological membranes, particularly into target tissues for protein synthesis or signaling. In a clinical context, it refers to optimizing the bioavailability of essential building blocks required for tissue repair and endocrine support. Effective delivery ensures that precursors for hormones and enzymes reach their sites of action without degradation.
Origin
The concept originates from foundational biochemistry describing protein synthesis (translation) where amino acids are linked sequentially via peptide bonds. In applied physiology, it relates to novel delivery systems engineered to bypass normal digestive barriers or improve cellular uptake kinetics. This term highlights the practical challenge of nutrient absorption in compromised physiological states.
Mechanism
Successful delivery often relies on specific transport mechanisms, such as carrier-mediated uptake or endocytosis, depending on the chain length and molecular structure. For di- and tripeptides, specific intestinal transporters may be utilized, offering advantages over free amino acid absorption. This process is critical for maintaining adequate substrate availability for anabolic processes and maintaining lean body mass.
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