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Alzheimer’s Disease

Meaning

Alzheimer’s Disease is a progressive neurodegenerative disorder characterized by cognitive decline, memory loss, and behavioral changes. From an endocrinological perspective, this pathology is increasingly linked to dysregulation of glucose metabolism and insulin signaling within the central nervous system, often referred to as ‘Type 3 Diabetes.’ This condition involves the formation of extracellular amyloid-beta plaques and intracellular neurofibrillary tangles composed of hyperphosphorylated tau protein. The resulting neuronal damage and synaptic loss profoundly disrupt communication pathways essential for memory and executive function.