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Allosteric Modulation

Meaning

Allosteric Modulation is a fundamental biochemical process where a molecule, known as an allosteric modulator, binds to a site on a protein—such as a hormone receptor or enzyme—that is distinct from the primary active or orthosteric site. This binding induces a conformational change in the protein structure, altering the affinity or efficacy of the primary ligand, like a hormone or neurotransmitter, for its own binding site. This mechanism offers a precise way to fine-tune the body’s hormonal and signaling responses without directly competing with the natural ligand.