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Allostatic Resistance

Meaning

Allostatic Resistance is the physiological capacity to withstand and adapt effectively to chronic stress and allostatic load without incurring significant wear and tear on the body’s systems. This resilience represents the robustness of the neuroendocrine and immune systems to maintain dynamic stability, or allostasis, in the face of persistent challenges. A high degree of allostatic resistance indicates a system capable of efficient hormonal and metabolic recovery, minimizing the cumulative cost of stress. It is a critical, measurable marker of overall healthspan and longevity potential in clinical endocrinology.