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Allostatic Load Theory

Meaning

A scientific model describing the cumulative, long-term physiological cost of chronic stress exposure and the repeated or prolonged activation of the body’s allostasis systems. Allostasis, meaning “achieving stability through change,” involves the brain and multiple organ systems, including the HPA axis and the sympathetic nervous system, adapting to environmental demands. When these systems are overtaxed, the resulting allostatic load manifests as wear and tear on the body, contributing to disease and accelerated aging.