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Allostatic Load Reversal

Meaning

Allostatic Load Reversal is the clinical and physiological process of actively reducing the cumulative wear and tear on the body’s systems resulting from chronic, repeated efforts to maintain stability (allostasis) in the face of persistent stress. This reversal involves implementing targeted interventions to restore the hypothalamic-pituitary-adrenal (HPA) axis, cardiovascular, metabolic, and immune systems to a state of lower burden and improved resilience. Achieving reversal is critical for mitigating the long-term health consequences of chronic stress, which manifest as increased risk for various age-related and chronic diseases. The goal is to shift the physiological set points back toward optimal function.