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Allopregnanolone Signaling

Meaning

This term refers to the intricate communication pathway mediated by Allopregnanolone, a potent endogenous neurosteroid derived from progesterone. Allopregnanolone functions as a positive allosteric modulator of the GABA-A receptor complex in the central nervous system. This signaling cascade is fundamental for regulating mood, anxiety, stress response, and sleep architecture within the brain. Clinically, fluctuations in this signaling are implicated in various neuropsychiatric conditions, highlighting its crucial role in maintaining neural equilibrium.