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Allopregnanolone Neurogenesis

Meaning

Allopregnanolone neurogenesis refers to the process by which the neurosteroid allopregnanolone, a potent positive allosteric modulator of the GABA-A receptor, stimulates the proliferation and differentiation of new neurons in the adult brain, primarily within the hippocampus. This action highlights a crucial, regenerative role for this progesterone metabolite in maintaining central nervous system plasticity and function. Clinically, this biological activity is particularly relevant for addressing conditions associated with impaired neurogenesis, such as major depressive disorder and cognitive decline. The neurosteroid’s influence extends beyond simple sedation, promoting structural health in neural circuitry.