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Allopregnanolone Dysregulation

Meaning

Allopregnanolone dysregulation describes an aberrant concentration and function of allopregnanolone, a potent neurosteroid derived from progesterone, within the central nervous system. Clinically, this imbalance involves either excessively low or pathologically elevated levels, which compromises its critical inhibitory role in the brain. Such hormonal deviation is frequently implicated in the manifestation of various mood and anxiety disorders, highlighting its profound significance in psychiatric endocrinology and emotional well-being. This dysregulation is a key focus when assessing the neurobiological underpinnings of conditions like postpartum depression and premenstrual dysphoric disorder.