Skip to main content

Allan-Herndon-Dudley Syndrome

Meaning

Allan-Herndon-Dudley Syndrome (AHDS) is a rare, X-linked neurodevelopmental disorder primarily characterized by severe intellectual disability, speech deficits, and movement problems. This condition represents a form of congenital thyroid hormone resistance specifically affecting the central nervous system. The clinical presentation includes infantile hypotonia followed by spasticity and muscle hypoplasia, which significantly limits motor function and mobility in affected males.