All-cause mortality markers are specific biological, physiological, or lifestyle indicators whose abnormal levels or presence are statistically associated with an increased risk of death from any underlying cause. These markers serve as powerful predictors of overall healthspan and lifespan, reflecting the cumulative burden of systemic dysfunction. Monitoring these objective parameters offers a quantitative means to assess an individual’s biological resilience and disease vulnerability.
Origin
The systematic study of mortality markers evolved from epidemiological research focused on identifying risk factors for chronic diseases and age-related decline. This concept integrates findings from various medical disciplines, including cardiology, endocrinology, and gerontology, moving beyond disease-specific risk assessment to a holistic measure of biological integrity. Advanced longitudinal studies are instrumental in validating the predictive power of these indicators across diverse populations.
Mechanism
The mechanism involves reflecting fundamental processes of aging and disease pathology, such as chronic inflammation, metabolic dysregulation, and cellular senescence. Elevated C-reactive protein, aberrant lipid profiles, poor glycemic control, or low cardiorespiratory fitness all represent systemic deviations from optimal function. By signaling a compromise in homeostatic capacity, these markers indicate a diminished ability to withstand physiological stress, thus increasing the likelihood of death from any event.
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