What is the Origin of Aldosterone Synthase?

The term combines "aldosterone," the steroid hormone it produces, and "synthase," a general biochemical term indicating an enzyme that catalyzes a synthesis reaction. Aldosterone itself derives its name from the adrenal cortex where it is synthesized and its chemical nature as a steroid. As a key component of the Renin-Angiotensin-Aldosterone System, its biological origin lies in the adrenal gland's zona glomerulosa.

What is the Mechanism of Aldosterone Synthase?

This enzyme catalyzes three sequential reactions within the adrenal mitochondria, utilizing deoxycorticosterone as its primary substrate. Specifically, it performs 11-beta-hydroxylation, 18-hydroxylation, and subsequent 18-oxidation to form the final active hormone, aldosterone. Angiotensin II and potassium levels are the primary physiological regulators of Aldosterone Synthase expression and activity. The resulting aldosterone acts on the kidneys to promote sodium reabsorption and potassium excretion, thus modulating blood volume.

Aldosterone Synthase

Meaning

Aldosterone Synthase, also known as CYP11B2, is a crucial enzyme within the adrenal cortex responsible for the final steps of aldosterone biosynthesis. This cytochrome P450 enzyme converts 11-deoxycorticosterone into corticosterone, then into 18-hydroxycorticosterone, and finally into the potent mineralocorticoid aldosterone. Its function is essential for regulating blood pressure, electrolyte balance, and overall fluid homeostasis in the body. Dysregulation of this enzyme can lead to conditions like primary aldosteronism, impacting cardiovascular health significantly.

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How Do Genetic Variations Affect Dietary Responses for Fluid Balance?

Your unique genetic blueprint dictates how your body manages fluid in response to diet, shaping your personal path to metabolic balance.

∞ ACE Gene Polymorphism
∞ Salt Sensitivity
∞ Fluid Balance

HRTioJuly 31, 2025

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Can Personalized Dietary Sodium Recommendations Optimize Outcomes in Hormone Therapy?

Personalized sodium intake is a critical tool to manage fluid balance and blood pressure during hormone therapy.

∞ Testosterone Cypionate
∞ Fluid Balance
∞ Water Retention

HRTioJuly 31, 2025

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Can Lifestyle Adjustments Mitigate Genetically Predicted Fluid Retention on Hormone Therapy?

Lifestyle adjustments can effectively counteract genetically influenced fluid retention on HRT by managing the RAAS system.

∞ Aldosterone Synthase
∞ Blood Pressure
∞ Lymphatic Drainage

HRTioJuly 26, 2025

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How Do Genetic Tests for Fluid Retention Risk Compare with Traditional Diagnostic Methods?

Genetic tests reveal inherent fluid retention predispositions, offering a proactive complement to traditional diagnostics for personalized wellness protocols.

∞ Metabolic Function
∞ Antidiuretic Hormone
∞ Epithelial Sodium Channel

HRTioAugust 24, 2025

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What Specific Genetic Tests Can Predict Fluid Retention Risk on Hormone Therapy?

Genetic tests analyzing RAAS and hormone metabolism pathways reveal your unique, predictable predisposition to fluid retention on hormone therapy.

∞ Genetic Polymorphisms
∞ Mineralocorticoid Receptor
∞ Hormonal Optimization Protocol

HRTioAugust 23, 2025

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How Do Individual Genetic Variations Influence Fluid Retention on Hormonal Protocols?

Individual genetic variations alter hormone metabolism and receptor sensitivity, directly influencing fluid retention during hormonal protocols.

∞ Hormonal Protocols
∞ Testosterone Replacement Therapy
∞ Fluid Dynamics

HRTioJuly 19, 2025

Aldosterone Synthase

Meaning

Origin

Mechanism

How Do Genetic Variations Affect Dietary Responses for Fluid Balance?

Can Personalized Dietary Sodium Recommendations Optimize Outcomes in Hormone Therapy?

Can Lifestyle Adjustments Mitigate Genetically Predicted Fluid Retention on Hormone Therapy?

How Do Genetic Tests for Fluid Retention Risk Compare with Traditional Diagnostic Methods?

What Specific Genetic Tests Can Predict Fluid Retention Risk on Hormone Therapy?

How Do Individual Genetic Variations Influence Fluid Retention on Hormonal Protocols?

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