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Aldosterone Antagonist

Meaning

Aldosterone antagonists are a class of pharmaceutical agents that specifically interfere with the biological actions of the mineralocorticoid hormone aldosterone. These medications function by binding to and blocking the aldosterone receptor, primarily in the distal convoluted tubule and collecting duct of the kidney. Clinically, they are utilized to manage conditions characterized by excessive aldosterone activity, such as hypertension, heart failure, and edema, promoting diuresis and potassium retention. They play a critical role in fluid and electrolyte balance, directly impacting cardiovascular and renal health.