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AKR1D1

Meaning

Aldosterone-Keto Reductase 1 Member D1 is a hepatic enzyme known scientifically as Steroid 5β-reductase, a critical component in the metabolism of endogenous steroid hormones. This enzyme is highly expressed in the liver, serving a pivotal role in the clearance and deactivation of major steroid classes, including glucocorticoids and androgens. Clinically, its activity level can influence the circulating concentrations of powerful hormones like cortisol and testosterone, directly impacting their biological availability and overall systemic effects.