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AKR1C2

Meaning

AKR1C2, or Aldo-Keto Reductase Family 1 Member C2, is a human enzyme primarily known for its role in steroid hormone metabolism, particularly the reduction of 5α-dihydrotestosterone (DHT) into the less potent androgen, 5α-androstane-3α,17β-diol (3α-diol). This enzyme is a critical component in regulating the bioavailability and activity of potent androgens within various tissues. Clinical endocrinology recognizes this enzyme as a key player in conditions influenced by androgen levels, such as prostate health and certain hormonal imbalances. Its function directly impacts the local concentration of highly active hormones, thus influencing cellular signaling.