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AKR1C

Meaning

AKR1C refers to the aldo-keto reductase family 1 member C enzymes, a group of enzymes critical in the metabolism of various steroid hormones and prostaglandins within the human body. These enzymes, specifically isoforms like AKR1C1, AKR1C2, and AKR1C3, play a pivotal role in regulating the active concentrations of androgens, estrogens, and progesterone. Understanding the function of these enzymes is essential for assessing steroid hormone bioavailability and action in clinical practice. Their activity can significantly influence the balance between active and inactive hormone forms, impacting overall hormonal health and tissue response.