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AIP Gene

Meaning

The AIP Gene, or Aryl Hydrocarbon Receptor Interacting Protein gene, is a tumor suppressor gene whose mutation is associated with a predisposition to develop pituitary adenomas. These are typically benign tumors of the pituitary gland that can lead to excessive or deficient hormone secretion, profoundly disrupting the body’s endocrine balance. When mutated, it is a primary cause of Familial Isolated Pituitary Adenomas (FIPA) and is notably linked to aggressive, large-sized tumors, particularly those secreting growth hormone. Recognizing a germline AIP mutation is vital for early screening and aggressive management in affected families.