AIMP1 Peptide ∞ Area

AIMP1 Peptide

Meaning

AIMP1 (Aminoacyl tRNA Synthetase Complex-Interacting Multifunctional Protein 1), also known as p43, is a component of the multi-tRNA synthetase complex (MSC). It is released from cells, acting as a cytokine or growth factor, and functions as an angiogenin, promoting blood vessel formation and playing roles in inflammation and immune regulation. As a peptide, it refers to specific active fragments or the full protein acting in a signaling capacity.

Context

AIMP1 operates within the extracellular matrix and various tissues, released from cells primarily in response to stress or inflammation. It is recognized as an alarmin, signaling cellular damage or danger to the immune system. Its involvement extends to tissue repair processes and modulating immune responses, positioning it as a critical mediator in physiological and pathophysiological conditions.

Significance

The clinical significance of AIMP1 peptide lies in its dual role in both promoting tissue repair and contributing to inflammatory conditions. Its presence can indicate ongoing cellular stress or injury, influencing the progression of diseases characterized by aberrant angiogenesis or chronic inflammation. Understanding its activity aids in assessing disease severity and potential therapeutic targets.

Mechanism

AIMP1 exerts its effects by binding to specific cell surface receptors, including CXCR4, initiating intracellular signaling cascades. This interaction can lead to downstream activation of pathways involved in cell proliferation, migration, and the secretion of other pro-inflammatory cytokines. Its angiogenin activity is mediated through the induction of endothelial cell migration and tube formation.

Application

In clinical practice, AIMP1 peptide is not directly applied as a therapeutic agent in widespread protocols; rather, its modulation or detection is being investigated for diagnostic and prognostic purposes. Research explores its potential as a biomarker for certain cancers, inflammatory disorders, or cardiovascular conditions where angiogenesis or immune dysregulation are prominent features.

Metric

Levels of AIMP1 can be measured in biological fluids such as serum or plasma using immunoassay techniques, including ELISA. Tissue expression can be assessed through immunohistochemistry or Western blot analysis. These measurements provide insights into its systemic presence and localized activity, aiding in research and potentially future diagnostic panels.

Risk

Direct clinical application of AIMP1 peptide is not standard, thus specific risks from its therapeutic use are not established. However, dysregulated AIMP1 activity, particularly overexpression, is associated with pathological conditions like tumor growth and chronic inflammation. Its uncontrolled promotion of angiogenesis could theoretically exacerbate conditions requiring vascular control.

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HRTioAugust 3, 2025

AIMP1 Peptide

Meaning

Context

Significance

Mechanism

Application

Metric

Risk

How Do Peptides Influence Hair Follicle Stem Cells?

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