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AGT Gene

Meaning

The AGT gene, or Angiotensinogen gene, provides instructions for creating the angiotensinogen protein, a crucial precursor in the Renin-Angiotensin-Aldosterone System, or RAAS. This system is a primary endocrine regulator of blood pressure, fluid balance, and electrolyte homeostasis in the human body. Variations in this gene are clinically relevant as they can influence circulating angiotensinogen levels, thereby affecting an individual’s predisposition to hypertension and cardiovascular risk. Understanding an individual’s AGT genotype helps clinicians personalize treatment strategies for managing blood pressure and related hormonal imbalances.