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AgRP Antagonism

Meaning

AgRP Antagonism refers to the pharmacological or physiological action of blocking the activity of the Agouti-related peptide, a potent orexigenic neuropeptide found primarily in the hypothalamus. This antagonism effectively inhibits AgRP’s signaling at the melanocortin receptors, specifically MC3R and MC4R, which are crucial for regulating energy balance and appetite. Clinically, AgRP antagonism is a mechanism studied for its potential to reduce food intake and promote negative energy balance, thereby serving as a target in the management of obesity and related metabolic dysfunctions.