Skip to main content

Agrin

Meaning

Agrin is a large, secreted heparan sulfate proteoglycan that plays a fundamental role in the formation and maintenance of the neuromuscular junction, the specialized synapse between a motor neuron and a skeletal muscle fiber. In the broader context of hormonal health, its signaling pathways are intrinsically linked to factors that regulate muscle mass, strength, and metabolic function. It is a critical component of the extracellular matrix that organizes synaptic structures.