Aging Process Deceleration is a clinical objective focused on intervening in the fundamental physiological decline associated with chronological progression, specifically targeting the molecular and systemic factors that drive senescence. This approach seeks to maximize healthspan by optimizing endocrine and cellular resilience rather than merely extending survival time. We are modulating the rate of biological deterioration.
Origin
This concept is sourced from the fields of gerontology and longevity science, where ‘deceleration’ implies an active intervention designed to slow the accumulation of cellular damage and functional entropy. It is fundamentally rooted in understanding the established hallmarks of aging pathways. The term implies a proactive, rather than passive, relationship with time.
Mechanism
This deceleration often involves strategic modulation of key longevity pathways, such as fine-tuning the Insulin/IGF-1 axis signaling or supporting NAD+ dependent sirtuin activity through specific interventions. Optimizing mitochondrial biogenesis and reducing persistent low-grade inflammation are also critical components. Successful deceleration relies on improving cellular energy sensing to favor anabolic maintenance over catabolic breakdown.
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