This term clinically refers to the maintenance of optimal cognitive function, neural integrity, and neuroendocrine balance across the lifespan, specifically mitigating the physiological decline associated with advancing age. It encompasses the resilience of neuronal networks and the sustained capacity for memory, executive function, and emotional regulation, which are all highly sensitive to hormonal fluctuations. The goal is to preserve a high level of neuroplasticity and synaptic efficiency, key hallmarks of a functionally young brain.
Origin
The concept stems from the convergence of gerontology, neuroscience, and endocrinology, recognizing the brain’s unique susceptibility to age-related changes and the critical modulatory role of the endocrine system. It evolved as clinical practice shifted from treating established neurodegenerative disease to proactive, preventative neuroprotection and longevity medicine. This holistic view acknowledges that brain health is inextricably linked to systemic hormonal homeostasis.
Mechanism
Hormonal mechanisms, such as the balanced pulsatile release of Growth Hormone, the neurosteroid activity of DHEA and Pregnenolone, and the stability of the thyroid axis, are central to this health state. These endocrine signals modulate neurotrophic factor expression, reduce oxidative stress in the central nervous system, and influence amyloid and tau protein metabolism. Maintaining youthful hormone signaling pathways is crucial for supporting mitochondrial function within neurons and preserving the integrity of the blood-brain barrier.
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