A comprehensive, proactive clinical plan designed to preserve optimal physiological function and mitigate the biological hallmarks of aging. This strategy extends beyond simple disease management to actively support cellular vitality, hormonal balance, and tissue resilience. The goal is to compress the period of morbidity and extend healthspan by systematically addressing the root causes of age-related decline. It represents a paradigm shift from reactive treatment to preemptive, longevity-focused intervention.
Origin
This term is a conceptual construct within the modern longevity and anti-aging medicine movement, blending preventative health principles with advanced biological science. It draws heavily from gerontology and endocrinology, synthesizing research on cellular senescence, telomere dynamics, and the decline of key endocrine axes. The ‘strategy’ component emphasizes a structured, personalized clinical approach rather than a single intervention.
Mechanism
An effective Ageproofing Strategy operates by modulating critical physiological pathways, including nutrient sensing, cellular repair via autophagy, and inflammation control. Key hormonal mechanisms are targeted, such as optimizing insulin sensitivity and maintaining the diurnal rhythm of cortisol and sex steroids. Interventions are personalized, often incorporating precision nutrition, targeted supplementation, and lifestyle adjustments to sustain the homeostatic capacity of the endocrine system and somatic tissues.
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