A specialized nutritional paradigm focused on optimizing cellular function and endocrine signaling pathways to sustain peak physical and cognitive performance across the lifespan. This approach moves beyond general dietary guidelines, integrating advanced understanding of metabolic adaptation, hormone sensitivity, and nutrient timing. It is a clinical strategy designed to mitigate age-related decline in physiological reserves by providing precise molecular fuel. The goal is to maximize vitality and functional capacity rather than simply managing chronic disease.
Origin
This concept synthesizes principles from clinical endocrinology, gerontology, and sports nutrition, evolving from the broader field of anti-aging medicine and personalized wellness. The term reflects a shift in focus from mere lifespan extension to healthspan extension, emphasizing sustained high-level functioning. It acknowledges the critical interplay between dietary substrate and the body’s hormonal and enzymatic machinery.
Mechanism
The core mechanism involves targeted modulation of key longevity pathways, such as mTOR, AMPK, and sirtuins, through specific macronutrient ratios and micronutrient delivery. By managing insulin sensitivity and reducing systemic inflammation, this nutritional strategy supports optimal hormonal milieu for tissue repair and maintenance. Furthermore, it provides essential cofactors for steroidogenesis and neurotransmitter synthesis, thereby directly influencing mood, energy, and muscle anabolism.
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