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Age Systems Failure

Meaning

Age Systems Failure represents the concurrent, cumulative decline in the functional integrity and homeostatic capacity of multiple physiological systems across the lifespan. This concept moves beyond single-organ senescence to describe the critical, interconnected breakdown of key regulatory networks, including the neuroendocrine, immune, and metabolic axes. It signifies a profound loss of resilience, ultimately leading to increased vulnerability to pathology and accelerated biological aging. Clinically, recognizing this systemic decompensation is crucial for implementing targeted longevity interventions.