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Age Stratified Response

Meaning

This concept refers to the principle in clinical endocrinology and pharmacology that the physiological or therapeutic effect of an intervention, such as hormone replacement or a pharmaceutical agent, is significantly dependent on the chronological and biological age of the patient. The body’s capacity for homeostatic adaptation and receptor sensitivity changes dramatically across decades, necessitating age-specific dosing and treatment protocols. Recognizing the differential response across age groups is essential for maximizing efficacy and minimizing adverse events in personalized medicine. Clinicians must account for age-related changes in organ function and metabolic clearance when initiating new therapies.