The clinical application of exogenous hormones, tailored precisely to the individual’s current chronological age and specific endocrine profile, rather than a standardized protocol. This approach recognizes that hormonal requirements shift significantly across the lifespan. Precise dosing supports physiological homeostasis rather than supra-physiological stimulation.
Origin
This methodology evolved from traditional hormone replacement therapy by integrating principles of chronobiology and personalized endocrinology. It signifies a shift toward dynamic, age-adjusted physiological support.
Mechanism
Therapy involves carefully calibrating the administration of specific agents, such as estrogens, androgens, or thyroid modulators, to match the body’s diminishing endogenous production capacity at different life stages. The goal is to maintain target tissue responsiveness and receptor signaling fidelity. This tuning aims to support cellular function across target organs, including neural structures.
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