Clinical and scientific interventions designed to actively reduce an individual’s biological age, as measured by validated biomarkers, aiming to restore cellular and tissue function to a more youthful state. These sophisticated strategies move beyond merely slowing aging to promoting genuine biological rejuvenation. The ultimate goal is to compress morbidity, allowing for a longer, healthier period of life.
Origin
This term emerges from the intersection of regenerative medicine, longevity science, and molecular biology, transitioning from theoretical possibility to applied clinical practice. The foundation lies in understanding the Hallmarks of Aging and developing targeted methods to address these fundamental biological processes.
Mechanism
Therapies typically focus on key biological pathways, including the clearance of senescent cells (senolytics), epigenetic reprogramming, enhancing mitochondrial biogenesis, and optimizing systemic signaling molecules. Hormonal modulation, particularly the restoration of youthful endocrine profiles, is a critical component, acting as a master regulator for numerous regenerative cascades.
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