An Age Reversal Proxy is a measurable biological marker or composite score used in longevity medicine to indirectly assess the degree of biological age deceleration or apparent reversal. This term acknowledges the current clinical inability to truly reverse chronological aging, instead focusing on quantifiable improvements in biological metrics. Clinicians use these proxies, such as epigenetic clocks or telomere length, to gauge the efficacy of therapeutic interventions on the aging process. It serves as a practical, actionable indicator of systemic rejuvenation.
Origin
This term is a construct born out of the burgeoning field of geroscience and preventative medicine, merging biological measurement with clinical outcome assessment. The concept relies on the scientific understanding that biological age, governed by cellular and molecular changes, can diverge from chronological age. The word ‘proxy’ highlights its function as a substitute measurement for the complex, multi-systemic process of aging.
Mechanism
The function of a proxy relies on its sensitivity to interventions that modulate fundamental aging pathways, such as cellular senescence or DNA methylation patterns. For example, a successful longevity protocol would induce epigenetic modifications that result in a younger predicted biological age on a validated clock. These proxies operate by reflecting changes in underlying physiological systems, often linked to key hormones like growth hormone or DHEA, which influence cellular repair and regeneration.
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