The scientific discipline focused on understanding and therapeutically manipulating the biological processes within the nervous system to restore cellular and functional characteristics associated with a younger chronological age. This field integrates concepts from endocrinology, genetics, and neurophysiology to address age-related decline in cognitive and autonomic functions. The ultimate goal is to enhance neuroplasticity and mitigate the structural degradation commonly observed in the aging brain. Clinical application seeks to leverage hormonal signaling pathways that influence neuronal health and repair.
Origin
This term emerges from the confluence of modern gerontology, neuroscience, and regenerative medicine, gaining prominence with advances in epigenetics and brain-body communication research. The concept builds upon the established neuroendocrinology framework, which recognizes the reciprocal influence between hormones and the central nervous system. Its modern clinical interpretation reflects a shift from merely slowing aging to actively seeking systemic rejuvenation.
Mechanism
Core mechanisms involve modulating key neuroendocrine axes, such as the hypothalamic-pituitary-adrenal (HPA) and hypothalamic-pituitary-gonadal (HPG) axes, to restore youthful signaling patterns. This modulation includes enhancing neurotrophic factor expression, promoting synaptic integrity, and clearing senescent cells and accumulated protein aggregates from neural tissue. Furthermore, it often targets mitochondrial function within neurons and glial cells to improve overall brain energy dynamics.
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