A comprehensive, multi-faceted clinical framework aimed at quantitatively reducing an individual’s biological age relative to their chronological age, as measured by established epigenetic and physiological biomarkers. This methodology is centered on the principle of restoring youthful cellular function and reversing specific markers of senescence across multiple organ systems. It represents a systematic application of longevity science principles within a clinical setting to enhance healthspan.
Origin
This term emerges from the convergence of gerontology, regenerative medicine, and bio-optimization, particularly gaining traction with the development of epigenetic clocks that allow for the measurable assessment of biological aging. The concept moves beyond mere “anti-aging” to define a structured, actionable process with measurable outcomes in reversing the trajectory of physiological decline. Its foundation lies in the clinical translation of fundamental research into the hallmarks of aging.
Mechanism
The core mechanism involves modulating key drivers of cellular aging, such as telomere shortening, epigenetic drift, and mitochondrial dysfunction. Strategies often include targeted hormonal optimization, specific peptide therapies, and interventions that promote autophagy and cellular clearance. By systematically addressing these underlying molecular processes, the methodology seeks to reset cellular programming and enhance the regenerative capacity of tissues and organs.
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