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Age Related Tissue Dysfunction

Meaning

This term refers to the progressive decline in the structural integrity and functional capacity of various tissues and organs that occurs as a natural consequence of biological aging. It encompasses cellular senescence, telomere attrition, and accumulation of molecular damage, leading to impaired tissue repair and reduced homeostatic reserve. The clinical manifestation of this dysfunction includes sarcopenia, decreased bone density, and reduced endocrine gland responsiveness.