What is the Origin of Age-Related Tissue Catabolism?

Derived from the physiological concept of catabolism, which is the destructive phase of metabolism, combined with the factor of age-related decline, a core tenet of gerontology and endocrinology. The term situates the process within the context of biological senescence and associated hormonal shifts.

What is the Mechanism of Age-Related Tissue Catabolism?

Hormonal changes, particularly the decline in anabolic hormones like testosterone, growth hormone, and DHEA, drive this mechanism. Simultaneously, there is often an increase in catabolic signaling, such as elevated chronic low-grade inflammation and cortisol activity, further accelerating tissue breakdown. This imbalance disrupts cellular repair pathways and diminishes the body's ability to maintain structural integrity.

Age-Related Tissue Catabolism ∞ Area

Age-Related Tissue Catabolism

Meaning

The progressive, involuntary breakdown of complex tissue structures, such as muscle and bone, that occurs as a natural consequence of the aging process. This state reflects a shift in the body’s metabolic balance, where destructive catabolic processes begin to outweigh constructive anabolic processes. Clinically, this leads to a measurable decline in functional tissue mass and overall physical capacity.